| Date | Location | Result | |
| May 22, 2010 | Charleston, S.C. | High Point 16, Charleston Southern 11 | Box score |
| May 21, 2010 | Charleston, S.C. | High Point 10, Charleston Southern 8 | Box score |
| May 20, 2010 | Charleston, S.C. | High Point 15, Charleston Southern 7 | Box score |
| May 18, 2010 | Charleston, S.C. | UNC Wilmington 6, Charleston Southern 5 | Box score |
| May 16, 2010 | Asheville, N.C. | UNC Asheville 5, Charleston Southern 4 | Box score |
| May 15, 2010 | Asheville, N.C. | UNC Asheville 4, Charleston Southern 3 | Box score |
| May 14, 2010 | Asheville, N.C. | UNC Asheville 13, Charleston Southern 9 | Box score |
| May 12, 2010 | Columbia, S.C. | South Carolina 10, Charleston Southern 2 | Box score |
| May 11, 2010 | Statesboro, Ga. | Georgia Southern 12, Charleston Southern 7 | Box score |
| May 09, 2010 | Charleston, S.C. | LIBERTY 13, Charleston Southern 4 | Box score |
| May 08, 2010 | Charleston, S.C. | LIBERTY 4, Charleston Southern 1 | Box score |
| May 07, 2010 | Charleston, S.C. | LIBERTY 7, Charleston Southern 5 | Box score |
| Apr 24, 2010 | Charleston, S.C. | Gardner-Webb 5, Charleston Southern 4 | Box score |
| Apr 24, 2010 | Charleston, S.C. | Gardner-Webb 9, Charleston Southern 8 | Box score |
| Apr 23, 2010 | Charleston, S.C. | Charleston Southern 18, Gardner-Webb 4 | Box score |
| Apr 21, 2010 | Tallahassee, FL | Florida State 12, Charleston Southern 4 | Box score |
| Apr 18, 2010 | Clinton, S.C. | Charleston Southern 9, Presbyterian College 8 | Box score |
| Apr 17, 2010 | Clinton, S.C. | Presbyterian College 10, Charleston Southern 1 | Box score |
| Apr 16, 2010 | Clinton, S.C. | Presbyterian College 14, Charleston Southern 7 | Box score |
| Apr 13, 2010 | Wilmington, N.C. | UNC Wilmington 5, Charleston Southern 4 | Box score |
| Apr 11, 2010 | Charleston, S.C. | Winthrop 7, Charleston Southern 3 | Box score |
| Apr 10, 2010 | Charleston, S.C. | Winthrop 2, Charleston Southern 1 | Box score |
| Apr 09, 2010 | Charleston, S.C. | Charleston Southern 7, Winthrop 5 | Box score |
| Apr 07, 2010 | Greenville, S.C. | Charleston Southern 9, Furman 8 | Box score |
| Apr 06, 2010 | Charleston, S.C. | Charleston Southern 8, The Citadel 7 | Box score |
| Apr 03, 2010 | Radford, Va. | Radford 9, Charleston Southern 3 | Box score |
| Apr 03, 2010 | Radford, Va. | Charleston Southern 9, Radford 6 | Box score |
| Apr 02, 2010 | Radford, Va. | Charleston Southern 7, Radford 5 | Box score |
| Mar 31, 2010 | Charleston, S.C. | The Citadel 5, Charleston Southern 0 | Box score |
| Mar 30, 2010 | Mt. Pleasant, S.C. | College of Charlesto 9, Charleston Southern 4 | Box score |
| Mar 27, 2010 | Lexington, Va. | VMI 7, Charleston Southern 2 | Box score |
| Mar 27, 2010 | Lexington, Va. | Charleston Southern 1, VMI 0 | Box score |
| Mar 26, 2010 | Lexington, Va. | VMI 13, Charleston Southern 3 | Box score |
| Mar 24, 2010 | Charleston, S.C. | College of Charlesto 28, Charleston Southern 9 | Box score |
| Mar 23, 2010 | Savannah, Ga. | Charleston Southern 12, Savannah State 6 | Box score |
| Mar 20, 2010 | Charleston, S.C. | Coastal Carolina 29, Charleston Southern 13 | Box score |
| Mar 19, 2010 | Charleston, S.C. | Coastal Carolina 7, Charleston Southern 5 | Box score |
| Mar 17, 2010 | Charleston, S.C. | Charleston Southern 9, Savannah State 1 | Box score |
| Mar 16, 2010 | Spartanburg, S.C. | Charleston Southern 8, USC Upstate 5 | Box score |
| Mar 14, 2010 | Gainesville, Fla. | Charleston Southern 6, Florida 3 | Box score |
| Mar 13, 2010 | Gainesville, Fla. | Florida 16, Charleston Southern 10 | Box score |
| Mar 12, 2010 | Gainesville, Fla. | Florida 6, Charleston Southern 0 | Box score |
| Mar 10, 2010 | Charleston, S.C. | Georgia Southern 8, Charleston Southern 6 | Box score |
| Mar 09, 2010 | Charleston, S.C. | Charleston Southern 8, USC Upstate 4 | Box score |
| Mar 06, 2010 | Charleston, S.C. | Holy Cross 8, Charleston Southern 3 | Box score |
| Mar 06, 2010 | Charleston, S.C. | Charleston Southern 10, Holy Cross 6 | Box score |
| Mar 05, 2010 | Charleston, S.C. | Charleston Southern 7, Holy Cross 6 | Box score |
| Mar 03, 2010 | Mt. Pleasant, S.C. | College of Charlesto 12, Charleston Southern 7 | Box score |
| Feb 28, 2010 | Charleston, S.C. | Virginia Tech 13, Charleston Southern 1 | Box score |
| Feb 27, 2010 | Charleston, S.C. | Virginia Tech 4, Charleston Southern 2 | Box score |
| Feb 26, 2010 | Charleston, S.C. | Virginia Tech 17, Charleston Southern 2 | Box score |
| Feb 23, 2010 | Charleston, S.C. | Charleston Southern 7, Furman University 5 | Box score |
| Feb 21, 2010 | Charleston, S.C. | Charleston Southern 5, Virginia Commonwealt 2 | Box score |
| Feb 20, 2010 | Charleston, S.C. | Virginia Commonwealt 9, Charleston Southern 5 | Box score |
| Feb 19, 2010 | Charleston, S.C. | Virginia Commonwealt 7, Charleston Southern 5 | Box score |